The Tip Desk

Upstream Bio, Inc.

Company Stats

Market Cap
$288.6M
as of Sep 30, 2026
Shares Outstanding
54.8M
Free Float
63.6%

Income Statement

Revenue
$2.9M
Operating Income
-$160.4M
Net Income
-$143.4M
EBITDA
-$160.2M
FCF Margin, 3Y Avg
-2931.1%
FCF Margin, Worst Year
-4675.5%

Cash Flow

Free Cash Flow
-$133.4M
FCF Yield
-46.2%
Owner FCF Yield
-49.8%

Balance Sheet

Cash & Equivalents
$101.6M

Returns & Capital

SBC, 3Y Avg
$6.6M

Cash Flow by Year

YearRevenueFCFMargin
FY2025$2.9M-$133.4M-4675.5%
FY2024$2.4M-$59.7M-2518.3%
FY2023$2.4M-$38.1M-1599.6%

Annual filing data through FY ended December 31, 2025; shares and float as of October 6, 2026. Yields and enterprise value use the calculated market cap above, at its as-of date. Ratios are our calculations from reported figures.

Earnings

Other Coverage